San Diego · updated 13 November 2026

Top AI startups in San Diego

10 AI-native startups are based in San Diego. 4 were founded in the last three years.

  1. 1
    Fire Mountain Labs logo
    Fire Mountain LabsAmerican AI security and governance consultancy.Founded 2025
  2. 2
    type MAD1SON FOUNDRY logo
    type MAD1SON FOUNDRYType AI marketing agency based in San Diego and New York, specializing in AEO, GEO, and AI citation optimization.Founded 2020
  3. 3
    Velocity AI logo
    Velocity AIEnterprise AI agency, part of CourtAvenue.Founded 2025
  4. 4
    WeSpeak logo
    WeSpeakAI-powered omnichannel CRM for hotels, integrated with PMS and channel managers.Founded 2024
  5. 5Founded 2014
  6. 6Founded 2023
  7. 7
    MedCrypt logo
    MedCryptMedCrypt gives medical device vendors cybersecurity features in a few…Growth
  8. 8
    Elythea logo
    ElytheaML to predict and prevent pregnancy complications Early stage
  9. 9
    ZeroSettle logo
    ZeroSettleiMessage API for businesses and AI agentsEarly stage
  10. 10
    Integrated Reasoning logo
    Integrated ReasoningFaster processors for solving NP-complete problemsEarly stage

Related lists

Unicorns in San DiegoTop AI startups in San FranciscoTop AI startups in New York CityTop AI startups in SeattleTop AI startups in Palo AltoTop AI startups in Los AngelesTop AI startups in Boston

How this list is ranked

By a notability score built from public facts: valuation, a stock market listing, open-model downloads on Hugging Face, team size, a Wikidata entry and a verified owner. Nobody pays to rank higher. Rebuilt every morning. Methodology · Is your company here? Claim it.